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Overexpression of the endoplasmic reticulum 60 protein ER-60 downregulates ApoB100 secretion by inducing its intracellular degradation via a nonproteasomal pathway: evidence for an ER-60-mediated and phiCMB-sensitive intracellular degradative pathway
- Source :
- Biochemistry. April 27, 2004, Vol. 43 Issue 16, p4819, 13 p.
- Publication Year :
- 2004
-
Abstract
- Adenoviral expression vectors containing rat ER-60 cDNA were used to achieve dose and time dependent overexpression of ER-60 to investigate its role in apoB100 turnover. The data suggests an important role for ER-60 in promoting apoB100 degradation.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 43
- Issue :
- 16
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.123653427