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Alcohol inversion using cesium carboxylates and DMAP in toluene

Authors :
Hawryluk, Natalie A.
Snider, Barry B.
Schiesser, Carl H.
Greenberg, Marc M.
Robba, Max
Source :
Journal of Organic Chemistry. Dec 1, 2000, Vol. 65 Issue 24, p8379, 2 p.
Publication Year :
2000

Abstract

Inversion of secondary alcohols by the SN2 reaction of a cesium carboxylate with a secondary sulfonate in DMF is widely used in synthesis. A synthesis of DMAP catalyzing the displacement of secondary sulfonates by cesium carboxylates in toluene at reflux providing alternative to 18-crown-6 is discussed.

Subjects

Subjects :
Toluene -- Research
Toluene -- Chemical properties
Nucleophilic reactions -- Research
Cesium -- Research
Cesium -- Chemical properties
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00223263
Volume :
65
Issue :
24
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.123659881

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