Role of secondary structure in the asymmetric acylation reaction catalyzed by peptides based on chiral C(super alpha)-tetrasubstituted alpha-amino acids

Authors :: Formaggio, Fernando
Kaptein, Bernard
Barazza, Alessandra
Brazola, Elena
Bertocco, Andrea
Pengo, Paolo
Toniolo, Claudio
Pasquato, Lucia
Broxterman, Quirinus B.
Scrimin, Paolo
Source :: Journal of Organic Chemistry. May 28, 2004, Vol. 69 Issue 11, p3849, 8 p.
Publication Year :: 2004
Abstract: A set of analogues and dipeptide amides characterized by chiral C(super alpha)-tetrasubstituted alpha-amino acids of varied bulkiness and optical configurations are examined. Results confirm the close relationship between the beta-hairpin 3D-structure and the catalytic activity of the peptides.

Subjects :: Catalysts -- Usage
Peptides -- Research
Peptides -- Chemical properties
Chemistry, Organic -- Research
Biological sciences
Chemistry

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