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Peptide microarrays for the determination of protease substrate specificity

Authors :
Salisbury, Cleo M.
Maly, Dustin J.
Ellman, Jonathan A.
Source :
Journal of the American Chemical Society. Dec 18, 2002, Vol. 124 Issue 50, p14868, 3 p.
Publication Year :
2002

Abstract

An approach is described to obtain a complete analysis of protease specificity using microarrays of peptidyl coumarin substrates. These arrays are constructed using standard DNA microarraying equipment, using aldehyde-derivatized glass slides and alkoxylamine-functionaliized peptidyl coumarin substrates.

Details

Language :
English
ISSN :
00027863
Volume :
124
Issue :
50
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.123835241