Oxygenase activity in the self-hydroxylation of (S)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis

Authors :: Pinghua Liu
Mehn, Mark P.
Zongbao Zhao
Que, Lawrence, Jr.
Hung-wen Liu
Feng Yan
Source :: Journal of the American Chemical Society. August 25, 2004, Vol. 126 Issue 33, 10306-10312
Publication Year :: 2004
Abstract: Resonance Raman spectroscopic techniques and quinone staining are used to identify and study the biogenesis of hydroypropylphosphonic acid epoxidase (HppE). It is found that HppE can act as an oxygenase through a putative high valent iron-oxo or an iron-hydroperoxo intermediate.

Subjects :: Hydroxylation -- Research
Hydroxylation -- Optical properties
Chemical reactions
Chemistry

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