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Highly efficient and enantioselective cyclization of aromatic imines via imines via directed C-H bond activation

Authors :
Thaliji, Reema
Ellman, Jonathan A.
Bergman, Robert G.
Source :
Journal of the American Chemical Society. June 16, 2004, Vol. 126 Issue 23, 7192-7193
Publication Year :
2004

Abstract

A highly enantioselective and efficient method is developed for the intramolecular imine-directed C-H/olefin coupling reaction using chiral phosphoramidite ligands. The exceptional rates and enantioselectives observed using the phosphoramidite ligands may be due to their unique binding properties, which include reduced sigma donation to rhodium and enhanced pie acceptor ability compared to phosphines.

Details

Language :
English
ISSN :
00027863
Volume :
126
Issue :
23
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.124044978