Hydration of hydroxypyrrole influences binding of ImHpPyPy-beta-Dp polyamide to DNA

Authors :: Wellenzohn, Bernd
Loferer, Markus J.
Trieb, Michael
Rauch, Christine
Winger, Rudolf H.
Mayer, Erwin
Liedl, Klaus R.
Source :: Journal of the American Chemical Society. Jan 29, 2003, Vol. 125 Issue 4, p1088, 8 p.
Publication Year :: 2003
Abstract: A polyamide ligand is created (ImHpPyPy-beta-Dp), which segregates in a dimeric sequence among the four applicable basic pair levels in the smallest groove. This is an important identification for the design of DNA linking drugs, since such identification can be applicable in the large groove of DNA.

Subjects :: DNA -- Chemical properties
Polyamides -- Chemical properties
Pyrrole -- Chemical properties
Chemistry

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