Stereoselective synthesis of highly substituted delta1-pyrrolines: Exo-selective 1,3-dipolar cycloaddition reactions with azlactones

Authors :: Peddibhotla, Satyamaheshwar
Tepe, Jetze J.
Source :: Journal of the American Chemical Society. Oct 13, 2004, Vol. 126 Issue 40, p12776, 2 p.
Publication Year :: 2004
Abstract: A diastereoselective and efficient synthesis of highly substituted delta1-pyrroline-5-carboxylic acid scaffolds through a silver(I)-catalyzed [3 + 2] cycloaddition reaction is developed. The exo selectivity complements the endo-selective cycloaddition of related acyclic azomethine ylides very well.

Subjects :: Olefins -- Structure
Olefins -- Chemical properties
Carboxylic acids -- Chemical properties
Pyrrole -- Chemical properties
Chemistry

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