Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA)

Authors :: Peng Zhou
Miaomiao Wang
Lei Du
Fisher, Gregory W.
Waggoner, Alan
Ly, Danith H.
Source :: Journal of the American Chemical Society. June 11, 2003, Vol. 125 Issue 23, 6878-6879
Publication Year :: 2003
Abstract: Peptide nucleic acid (PNA) containing arginine side chains exhibited remarkable uptake properties while maintaining Watson-Crick recognition with complementary DNA strands is demonstrated. Evidence is provided that PNA could be selectively modified to facilitate uptake into mammalian cells.

Subjects :: Peptides -- Research
Guanidine -- Chemical properties
Nucleic acids -- Research
Chemistry

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