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Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA)
- Source :
- Journal of the American Chemical Society. June 11, 2003, Vol. 125 Issue 23, 6878-6879
- Publication Year :
- 2003
-
Abstract
- Peptide nucleic acid (PNA) containing arginine side chains exhibited remarkable uptake properties while maintaining Watson-Crick recognition with complementary DNA strands is demonstrated. Evidence is provided that PNA could be selectively modified to facilitate uptake into mammalian cells.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 125
- Issue :
- 23
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.124991075