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Accommodation of mispair aligned N(super 3)T-ethyl-N(super 3)T DNA interstrand cross link
- Source :
- Biochemistry. Oct 5, 2004, Vol. 43 Issue 39, p12549, 6 p.
- Publication Year :
- 2004
-
Abstract
- The structural properties underpinning the differences in the immediate environment of a N(super 3)T-ethyl-N(super 3)T interstrand cross link that is inserted into a scaffold wherein the cross link is mispair-aligned is described. Results demonstrate that the lesion defined by mismatch-aligned minor groove N(super 3)T-ethyl-N(super 3)T cross-linked thymine bases produces very localized distortions in a DNA stem that may be difficult to recognize by repair mechanisms that are not transcription-or-replication-coupled.
- Subjects :
- Biochemistry -- Research
DNA -- Research
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 43
- Issue :
- 39
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.125012683