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Cystic fibrosis in the mouse by targeted insertional mutagenesis
- Source :
- Nature. Sept 17, 1992, Vol. 359 Issue 6392, p211, 5 p.
- Publication Year :
- 1992
-
Abstract
- A new mouse model for cystic fibrosis (CF) has been devised that should be useful in trials of potential treatments for this deadly autosomal recessive disorder. The new model was produced through mutagenesis or the genetic disruption of the CF transmembrane conductance regulator gene in murine embryonic stem cells. The detection of the characteristic CF pathophysiology in the mice such as abnormal chloride ion transport verified the similarity of the model to human CF.
Details
- ISSN :
- 00280836
- Volume :
- 359
- Issue :
- 6392
- Database :
- Gale General OneFile
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.12658984