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Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site directed mutants

Authors :
Melet, Armelle
Schoch, Guillaume A.
Macherey, Anne-Christine
Jaoune, Maryse
Dansette, Patrick M.
Sari, Marie-Anges
Johnson, Eric F.
Mansuy, Daniel
Marques-Soares, Cristina
Source :
Biochemistry. Dec 14, 2004, Vol. 43 Issue 49, p15379, 14 p.
Publication Year :
2004

Abstract

The structural determinants of substrate specificity of human cytochrome P450 2C8(CYP2C8) are investigated using site-directed mutants chosen based on a preliminary substrate pharmacophore and a three-dimensional (3D) model.

Subjects

Subjects :
Cytochromes -- Research
Mutation (Biology) -- Analysis
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00062960
Volume :
43
Issue :
49
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.126728399

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