Enantiocontrolled synthesis of 2,6-distributed piperidines by desymmetrization of meso-eta- (3,4,5)-dihydropyridinylmolybdenum complexes: Application to the total synthesis of (-)-dihydropinidine and (-)-andrachcinidine

Enantiomerically pure iron and molybdenum pi-complexes are powerful scaffolds for the enantiocontrolled construction of substituted carbo- and heterocycles. A novel and enantiocontrolled synthesis of 2,6-disubstituted piperidines using a diastereoselective methoxide abstraction of dimethoxy complexes with chiral protecting groups is disclosed.