Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didnosine

Authors :: Miro, Oscar
Marinez, Esteban
Giralt, Marta
Vilarroya, Francesc
Casademont, Jordi
Concepcion, Marisa Rodriguez de la
Lopez, Sonia
Gsttsbou, Gloria
Pedrol, Enric
Gatell, Josep M.
Cardellach, Francesc
Source :: Journal of Acquired Immune Deficiency Syndromes (1999). Dec 15, 2004, Vol. 37 Issue 5, p1550, 6 p.
Publication Year :: 2004
Abstract: The certainty that the homeostatic mechanisms are able to compensate for this mtDNA depletion in patients receiving stavudine plus didnosine(d4T+ ddI), an antiretroviral combination with great in vitro and in vivo capacity to decrease mtDNA is determined. The study concludes that treatment with ddT=ddI is associated with decreased mitochondrial mass and mtDNA content but that cytochrome c oxidase subnit II (COX-II) expression and COX activity remain unaltered.

Subjects :: Stavudine -- Physiological aspects
Stavudine -- Chemical properties
Mitochondrial DNA -- Research
Antiviral agents -- Analysis
Antiviral agents -- Physiological aspects
Health

Tools