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A novel zinc finger coiled-coil domain in a family of nuclear proteins

Authors :
Reddy, Bramham A.
Etkin, Laurence
Freemont, Paul S.
Source :
Trends in Biochemical Sciences. Sept, 1992, Vol. 17 Issue 9, p344, 2 p.
Publication Year :
1992

Abstract

A new zinc-finger motif with the structure CX2CX9-27CXHX2CX6-17CX2C, where X is any amino acid, has been identified in a newly-discovered family of nuclear proteins. Apart from this motif, called the RING finger, several proteins in this family contain an associated B box motif and a coiled-coil domain. The B box and the coiled-coil domain in proteins such as T18 and PML may play an important role in the growth and differentiation of cells.

Details

ISSN :
09680004
Volume :
17
Issue :
9
Database :
Gale General OneFile
Journal :
Trends in Biochemical Sciences
Publication Type :
Academic Journal
Accession number :
edsgcl.12903817