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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
- Source :
- Nature. Nov 19, 1992, Vol. 360 Issue 6401, p225, 7 p.
- Publication Year :
- 1992
-
Abstract
- Research using mice with mutant T-cell antigen receptor (TCR) genes shows that rearrangement or expression of the TCR-beta gene is necessary and sufficient for differentiation of CD4-CD8-thymocytes into the CD4+CD8+ form and for expanding the pool of thymocytes. Expression of the TCR-alpha gene is irrelevant to these processes. Furthermore, the TCR-alpha and TCR-beta mutation does not hinder development of gamma and delta T-cells.
Details
- ISSN :
- 00280836
- Volume :
- 360
- Issue :
- 6401
- Database :
- Gale General OneFile
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.13035357