Functionalization of thiotic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins

Authors :: Abad, Jose M.
Mertens, Stijn F.L.
Pita, Marcos
Fernandez, Victor M.
Schiffrin, David J.
Source :: Journal of the American Chemical Society. April 20, 2005, Vol. 127 Issue 15, 5689-5694
Publication Year :: 2005
Abstract: An efficient strategy for the specific immobilization of fully functional proteins onto the surface of nanoparticles is described. The absence of nonspecific protein adsorption and the specificity of the binding site are verified using several analogues of the enzymes without the histidine tag.

Subjects :: Gold compounds -- Spectra
Proteins -- Research
Histidine -- Research
Chemistry

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