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Design of a calcium-binding protein with desired structure in a cell adhesion molecule

Authors :
Shang Yang
Wilkins, Anna L.
Yiming Ye
Zhi-ren Liu
Shun-yi Lu
Urbauer, Jeffrey L.
Hellinga, Homme W.
Kearney, Alice
van der Merwe, P. Anton
Jenny J. Wang
Source :
Journal of the American Chemical Society. Feb 23, 2005, Vol. 127 Issue 7, 2085-2093
Publication Year :
2005

Abstract

The successful design of a Ca(super 2+)- binding site in the non-Ca(super 2+)- binding cell adhesion protein CD2 is demonstrated. The designed protein, Ca.CD2, exhibits selectivity for Ca(super 2+) versus other di- and monovalent cations.

Details

Language :
English
ISSN :
00027863
Volume :
127
Issue :
7
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.132665890