Diastereoselective and enantioselective Rh(I)-catalyzed additions of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl aldimines

The highly diastereoselctive addition of arylboronic acids to both aromatic and aliphatic N-tert-butanesulfinyl imines as well as the initial disclosure of the highly enantioselective addition of aylboronic acids to N-diphenylphosphinoyl benzaldimine is reported. Two new highly practical methods for the asymmetric synthesis of alpha-branched amines are developed.