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Templated metal catalysis for single nucleotide specific DNA sequence detection

Authors :
Boll, Iris
Kramer, Roland
Brunner, Jens
Mokhir, Andriy
Source :
Journal of the American Chemical Society. June 1, 2005, Vol. 127 Issue 21, p7849, 8 p.
Publication Year :
2005

Abstract

A catalytic DNA-templated reaction of hydrolysis of an ester group in an N-modified peptide nucleic acid that is activated by a Cu(super 2+) complex-PNA is discovered and optimized. This reaction helps in developing a fully homogeneous and sensitive assay for sequence-specific DNA detection.

Subjects

Subjects :
Copper compounds -- Electric properties
Esters -- Research
Hydrolysis -- Research
DNA -- Research
Chemistry

Details

Language :
English
ISSN :
00027863
Volume :
127
Issue :
21
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.133342462

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