Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition

Authors :: Manzoni, Leonardo
Arosio, Daniela
Belvisi, Laura
Bracci, Antonio
Colombo, Matteo
Invernizzi, Donatella
Scolastico, Carlo
Source :: Journal of Organic Chemistry. May 13, 2005, Vol. 70 Issue 10, 4124-4132
Publication Year :: 2005
Abstract: An efficient and operationally simple method for the synthesis of functionalized azaoxobicyclo-[X.3.0]alkane amino acids is devised. The key step involves an intramolecular nitrone cycloaddition on 5-allyl- or 5-homoallylproline that was found to be completely regio- and stereoselective.

Subjects :: Acid-base chemistry -- Research
Alkanes -- Chemical properties
Amino acids -- Chemical properties
Biological sciences
Chemistry

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