Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity

Authors :: Lee-Huang, Sylvia
Young-Tae Chang
Mairov, Vladimir
Kallenbach, Neville
Huang, Philip L.
Huang, Paul L.
Ng, Angela
Hao-Chia Chen
Hee Chul Lee
Source :: Biochemistry. March 29, 2005, Vol. 44 Issue 12, p4648, 8 p.
Publication Year :: 2005
Abstract: Peptide fragmentation and activity mapping of human lysozyme was carried out in order to define the structural and sequence requirements for anti-HIV activity. The findings suggest that the effects of HL9 on signaling pathways involved in survival, stress, TGF(beta), p53, NF(kappa)B, protein kinase C and hedgehog signaling may reflect changes in host cells that affect susceptibility to infection.

Subjects :: Hedgehogs -- Research
Peptides -- Research
Protein kinases -- Research
Lysozyme -- Research
Biological sciences
Chemistry

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