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Thermodynamic and in vitro replication studies of an intrastrand G[8-5]C cross-link lesion

Authors :
Chunang Gu
Yinsheng Wang
Source :
Biochemistry. June 21, 2005, Vol. 44 Issue 24, p8883, 7 p.
Publication Year :
2005

Abstract

The steady-state kinetic measurements are extended to two replicative DNA polymerases, exonuclease-deficient T7 DNA polymerase T7(super -) and HIV reverse transcriptive (HIV-RT). The influences of G[8-5]C on the thermal stability and base pairing properties of DNA duplexes are examined.

Details

Language :
English
ISSN :
00062960
Volume :
44
Issue :
24
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.135258993