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Cis-acting expression quantitative trait loci in mice

Authors :
Doss, Sudheer
Schadt, Eric E.
Drake, Thomas A.
Lusis, Aldons J.
Source :
Genome Research. May, 2005, Vol. 15 Issue 5, 681-691
Publication Year :
2005

Abstract

A classic cis-trans test with [B6*DBA]F1 mice is utilized to determine the relative levels of transcripts from the B6 and DBA alleles. The results suggest that at least 64% of cis-acting expression quantitative trait loci (eQTL) with LOD >4.3 are true positives, while remaining 36% could not be confirmed as truly cis-acting.

Details

Language :
English
ISSN :
10889051
Volume :
15
Issue :
5
Database :
Gale General OneFile
Journal :
Genome Research
Publication Type :
Periodical
Accession number :
edsgcl.135554333