Structure, flexibility, and repair of two different orientations of the same alkyl interstrand DNA cross-links

Authors :: Noll, David M.
Silva, Mateus Webba da
Noronha, Anne M.
Wilds, Christopher J.
Colvin, O. Michael
Miller, Paul S.
Gamesik, Michael P.
Source :: Biochemistry. May 10, 2005, Vol. 44 Issue 18, 6764-6775
Publication Year :: 2005
Abstract: A study characterizes the repair, structure, and flexibility of DNA that contains N4C-ethyl-N4C interstand DNA cross-link in two different orientations. A combination of (super 1)H nuclear magnetic resonance (NMR), restrained molecular dynamics simulations, and atomic force microscopy (AFM) was used to examine the structure and flexibility of DNA containing these cross-links.

Subjects :: Atomic force microscopy -- Analysis
Molecular dynamics -- Analysis
DNA -- Structure
DNA -- Research
Biological sciences
Chemistry

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