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Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand
- Source :
- Journal of Bacteriology. Oct, 2005, Vol. 187 Issue 19-20, p6862, 5 p.
- Publication Year :
- 2005
-
Abstract
- We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from extension of mismatches produced by polymerase III holoenzyme.
Details
- Language :
- English
- ISSN :
- 00219193
- Volume :
- 187
- Issue :
- 19-20
- Database :
- Gale General OneFile
- Journal :
- Journal of Bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.137860923