Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study

Authors :: Strada, Ornelia
Vyas, Sheela
Hirsch, Etienne C.
Ruberg, Merle
Brice, Alexis
Agid, Yves
Javoy-Agid, France
Source :: Proceedings of the National Academy of Sciences of the United States. Oct 15, 1992, Vol. 89 Issue 20, p9549, 5 p.
Publication Year :: 1992
Abstract: An in situ hybridization study was done on the decreased acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease. It was shown that the level of expression of choline acetyltransferase mRNA in the nucleus basalis of Meynert from patients with Alzheimer disease was markedly decreased. These results suggest that the expression of choline acetyltransferase mRNA may be down-regulated in the cholinergic neurons identified in the nucleus basalis of Alzheimer patients.

Subjects :: Messenger RNA -- Physiological aspects
Alzheimer's disease -- Physiological aspects
Cholinergic mechanisms -- Physiological aspects
Neurons -- Physiological aspects
In situ hybridization -- Research
Science and technology

ISSN :: 00278424
Volume :: 89
Issue :: 20
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.13849852

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