Back to Search
Start Over
Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses
- Source :
- Proceedings of the National Academy of Sciences of the United States. Nov 1, 1992, Vol. 89 Issue 21, p10365, 5 p.
- Publication Year :
- 1992
-
Abstract
- Several questions regarding the physiological rules of immunity remain unanswered, resulting in limited progress in autoimmune diseases, transplantation tolerance, allergy and chronicinfectious diseases. To provide an explanation for the plasticity of the immunesystem, it is proposed that lymphocytes possess the ability to tune and update their responsiveness to recurrent signals. In this model, suprathreshold interactions represent processes such as cellular anergy, while subthreshold interactions represent functions such as immunological memory and control of infections.
- Subjects :
- Immune system -- Models
Immune response -- Models
Science and technology
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 89
- Issue :
- 21
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.13856532