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Characterization of neutral endopeptidase in vascular smooth muscle cells of rabbit renal cortex

Authors :
Dussaule, Jean-Claude
Stefanski, Adam
Bea, Marie-Luce
Ronco, Pierre
Ardaillou, Raymond
Source :
The American Journal of Physiology. Jan, 1993, Vol. 264 Issue 1, pF45, 8 p.
Publication Year :
1993

Abstract

The presence of neutral endopeptidase (NEP) in cultured vascular smooth muscle cells (VSMC) and its possible involvement in the degradation of atrial natriuretic factors (ANF) were investigated. Synthetic substrate hydrolysis, anti-NEP antibodies and Northern blot analysis revealed the presence of NEP in VSMC. Incubation of labeled ANF with VSMC and the NEP inhibitor thiorpan showed that NEP is involved in the catabolism of ANF by VSMC.

Details

ISSN :
00029513
Volume :
264
Issue :
1
Database :
Gale General OneFile
Journal :
The American Journal of Physiology
Publication Type :
Academic Journal
Accession number :
edsgcl.13912468