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Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase
- Source :
- Proceedings of the National Academy of Sciences of the United States. March 1, 1993, Vol. 90 Issue 5, p1711, 5 p.
- Publication Year :
- 1993
-
Abstract
- A high-flux screen of 2,000 compounds obtained from a chemical library resulted in the identification of alpha-anilinophenylacetamide(alpha-APA) derivatives as potent inhibitors of human immunodeficiency virus type 1 (HIV-1) replication. These inhibitors apparently target the viral reverse transcriptase and are effective at nanomolar concentrations. One of thederivatives, R 89439, has good oral availability, favorable pharmacokinetics and can be easily synthesized.
Details
- ISSN :
- 00278424
- Volume :
- 90
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.13982156