A gadolinium chelate for detection of beta-glucuronidase: A self-immolative approach

Authors :: Duimstra, Joseph A.
Femia, Frank J.
Meade, Thomas J.
Source :: Journal of the American Chemical Society. Sept 21, 2005, Vol. 127 Issue 37, p12847, 9 p.
Publication Year :: 2005
Abstract: A new class of magnetic resonance (MR) contrast agents that uses a self-immolative mechanism for activation in the presence of an enzyme is reported. A Gd(III) agent that is activated by the oncologically significant beta-glucuronidase is synthesized in nine steps.

Subjects :: Gadolinium -- Chemical properties
Chelates -- Chemical properties
Magnetic resonance -- Analysis
Chemistry

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