Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion

The crystal structures of native phosphatase of regenerating liver (PRL) -1 as well as the catalytically inactive mutant PRL-1/C104S in complex with sulfate are described. Structural and kinetic analyses place PRL-1 in the family of dual specificity phosphatases with closest structural similarity to the Cdc14 phosphatase and provide a molecular basis for catalytic activation of the PRL phosphatases.