Regulation of renal hemodynamics after protein feeding: effects of proximal and distal diuretics

Protein feeding results in the elevation of glomerular filtration rate, effective renal plasma flow and blood alpha amino nitrogen levels in dogs. Diuretics that act on the distal tubule did not modify this response to protein intake. However, diuretics that act on the proximal tubule completely negated this response. This suggest that reabsorption in the proximal tubule isan important event in effecting responses to protein feeding. Further, this results lend credence to the tubuloglomerular feedback hypothesis in the modulation of renal vasodilatory effect of meals.