Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication

Authors :: Mocarski, Edward S.
Bonyhadi, Mark
Salimi, Suzan
McCune, Joseph M.
Kaneshima, Hideto
Source :: Proceedings of the National Academy of Sciences of the United States. Jan 1, 1993, Vol. 90 Issue 1, p104, 5 p.
Publication Year :: 1993
Abstract: Severe combined immunodeficiency (SCID) mice implantedwith human fetal tissue can support the replication of human cytomegaloviruses (CMV). An investigation was conducted to determine whether the SCID-hu system could provide a model for human CMV infections and to identify the cellular targets of CMV. The results showed that SCID-hu mice could provide a good modelsystem for human CMV infections. The virus targeted the epithelial cells of thethymic medulla. Experiments also showed that ganciclovir is an effective suppressant of CMV replication in the tissue implant.

Subjects :: Animal models in research -- Research
Cytomegaloviruses -- Research
Thymus -- Research
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 1
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14051190

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