Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors

Authors :: Liu, Pei-Qi
Tan, Siyuan
Mendel, Matthew C.
Murrills, Richard J.
Bhat, Bheem M.
Schlag, Brian
Samuel, Rachelle
Matteo, Jeanne J.
de la Rosa, Ragan
Howes, Katherine
Reik, Andreas
Young, Kathleen
Gregory, Philip D.
Source :: Journal of Biomolecular Screening. June 2005, Vol. 10 Issue 4, p304, 10 p.
Publication Year :: 2005
Abstract: Isogenic cell lines differing only in the expression of the protein of interest provide the ideal platform for cell-based screening. However, related natural lines differentially expressing the therapeutic target of [...]

Subjects :: Gene expression -- Research
Protein research -- Research
Genetic transcription -- Research
Biological sciences
Research

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