Back to Search
Start Over
T cell receptor delta gene mutant mice: independent generation of alpha-beta T cells and programmed rearrangements of gamma-delta TCR genes
- Source :
- Cell. Feb 12, 1993, Vol. 72 Issue 3, p337, 12 p.
- Publication Year :
- 1993
-
Abstract
- Mutant mice deficient in gamma-delta T cell receptor (TCR) were generated to elucidate the molecular mechanisms of the expression of distinct subsets of gamma-delta T cells. The results showed that differential generation of gamma-delta T cell subsets involves an intracellular mechanism acting at the DNA rearrangement level. Furthermore, gamma-delta T cells are not required for the normal development of alpha-beta T cells.
- Subjects :
- T cells -- Receptors
Antibody diversity -- Research
Biological sciences
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 72
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14110663