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Crystal structure of Thermobifida fusca endoglucanase Ce16A in complex with substrate and inhibitor: The role of Tyrosine Y73 in substrate ring distortion
- Source :
- Biochemistry. Oct 4, 2005, Vol. 44 Issue 39, p12915, 8 p.
- Publication Year :
- 2005
-
Abstract
- Endoglucanase Ce16A from Thermobifida fusca hydrolyzes the beta-1,4 linkages in cellulose at accessible points along the polymer. The structure of the catalytic domain of Ce16A from T. fusca in complex with a nonhydrolysable structure analogue that acts as an inhibitor, methylcellobiosyl-4-thiobeta-cellobioside is determined to 1.5-angstrom resolution.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 44
- Issue :
- 39
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.141244628