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ASF1 binds to a hetrodimer of histone H3 and H4: A two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA
- Source :
- Biochemistry. Oct 25, 2005, Vol. 44 Issue 42, p13673, 10 p.
- Publication Year :
- 2005
-
Abstract
- The study was conducted on the assumption of deposition of histone H3-H4 heterotetramer onto DNA. Antisilencing function 1 (ASF1) is a major histone H3-H4 chaperone that deposits H3 and H4 onto DNA and single molecule of Asf1 binds to an H3-H4 hetrodimer using gel filteration, amino acid, reversed-phase chromatography and analytical ultracentrifugation analysis.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 44
- Issue :
- 42
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.141986691