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Mechanism of neurotrophic action of nobiletin in PC12D cells
- Source :
- Biochemistry. Oct 25, 2005, Vol. 44 Issue 42, p13683, 9 p.
- Publication Year :
- 2005
-
Abstract
- Nobility itself induces neurite outgrowth in PC12D cells, a rat pheochromocytoma cell line like NGF and the molecular mechanism of its neurotrophic action. The results suggest that nobiletin induces neurite outgrowth by activating a cAMP/PKA/MEK/Erk/MAP kinase-dependent but not TrkA-dependent signaling pathway coupling with CRE- mediated gene transcription and may become biochemical probe for elucidation of the molecular mechanism of neuronal differentiation.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 44
- Issue :
- 42
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.141986692