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Bacterial and retroviral superantigens share a common binding region on class II MHC antigens

Authors :
Torres, Barbara A.
Griggs, Nathan D.
Johnson, Howard M.
Source :
Nature. July 8, 1993, Vol. 364 Issue 6433, p152, 3 p.
Publication Year :
1993

Abstract

Synthetic peptides are used to detect a site on the mouse mammary tumour virus (MMTV)-1 superantigen that binds to class II major histocompatibility complex (MHC) antigens, which is surrounded by amino-acid residues 76-119 of the MMTV-1 superantigens. Experiments involving direct binding and competition reveal that the MMTV superantigen and Staphylococcal enterotoxin A (SEA) bind to atleast one common region on class II-MHC antigens.

Details

ISSN :
00280836
Volume :
364
Issue :
6433
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.14216350