Diastereomeric molecular recognition and binding behavior of bile acids by L/D-tryptophan-modified beta-cyclodextrins

Binding behavior of L-and D-trytophan-modified beta-cyclodextrins with four bile acids, which are cholate, deoxycholate, glycocholate and taurocholate, are investigated by fluorescence circular dichroism and 2D-NMR spectroscopies and fluorescence lifetime measurement. The combined use of the calorimetirc and NMR ROESY spectral examinations revealed the correlation between the thermodynamic parameters and the role of sidearm conformation in modified beta-cyclodextrins.