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Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate
- Source :
- Biochemistry. Dec 20, 2005, Vol. 44 Issue 50, p16563, 11 p.
- Publication Year :
- 2005
-
Abstract
- Study is conducted in which docked orientation for Cdc25B with its Cdk2-pTpY-CycA protein substrate is predicted by a rigid-body docking method and further the docked models with full-scale molecular dynamics simulations and minimization are refined. The stable ensemble structure is validated experimentally by a variety of in vitro techniques.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 44
- Issue :
- 50
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.142995261