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In situ preparation of protein- 'Smart' polymer conjugates with retention of bioactivity

Authors :
Heredia, Karina L.
Bontempo, Debora
Ly, Tiffany
Byers, Joshua T.
Halstenberg, Sven
Maynard, Heather D.
Source :
Journal of the American Chemical Society. Dec 7, 2005, Vol. 127 Issue 48, p16955, 6 p.
Publication Year :
2005

Abstract

A study demonstrates that bioactive 'smart' polymer conjugates could be synthesized by polymerizing from defined initiation sites on proteins, thus preparing the polymer conjugates in situ. Protein-polymer conjugates are widely used in biotechnology and medicine, and new methods to prepare the bioconjugates would be advantageous for these applications.

Details

Language :
English
ISSN :
00027863
Volume :
127
Issue :
48
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.144040220