Assessment of drug-drug interactions between tenofovir disoproxil fumarate and the nonnucleoside reverse transcriptase inhibitors nevirapine and efavirenz in HIV-infected patients

A study is conducted to assess the interactions between the drugs, namely tenofovir disoproxil fumarate (TDF) and the two nonnucleoside reverse inhibitors, nevirapine and efavirenz, which are used in the treatment of HIV-infected patients. The data obtained from the study demonstrates that these drugs, which can be co-administered without any need for dose adjustments, do not affect the plasma levels of the inhibitors.