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Chirospecific synthesis of (1S,3R)-1-amino-3-(hydroxymethyl)cyclopentane, a precursor for carbocyclic nucleoside synthesis: intramolecular aziridine cyclizations
- Source :
- Journal of Organic Chemistry. August 27, 1993, Vol. 58 Issue 18, p5019, 4 p.
- Publication Year :
- 1993
-
Abstract
- A study reveals the intramolecular cyclization of an ester enolate to a timulated aziridine, which is a part of a new technique of preparing an important precursor of carbocyclic nucleoside (1S, 3R)-1-amino-3-(hydroxymethyl)cyclopentane, as a result of which a substituted cyclopentane ring is formed. The intermediary of the bicyclic lactam ensures that a cyclopentane, which was formed as a mixture of diasteromers, was transformed to a single diasteromer.
- Subjects :
- Ring formation (Chemistry) -- Analysis
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00223263
- Volume :
- 58
- Issue :
- 18
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14545063