High-molecular-weight protein 2 of Yersinia enterocolitica is homologous to AngR of Vibrio anguillarum and belongs to a family of proteins involved in nonribosomal peptide synthesis

The high-molecular-weight protein 2 (HMWP2) of Yersinia enterocolitica is identical to AngR of Vibrio anguillarum in its structure, and may be involved in the nonribosomal preparation of small biologically active peptides. The nucleotide sequencing of the iron regulated irp 2 gene and its promoter region reveals the role of HMWP2, which is identical in many respects to the superfamily of enzymes that form adenylate. The irp2 gene, found exclusively in disease causing Yersinia species, encodes HMWP2.