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Molecular simplification in bioactive molecules: Formal synthesis of (+)-muconin
- Source :
- Journal of Organic Chemistry. March 17, 2006, Vol. 71 Issue 6, 2339-2345
- Publication Year :
- 2006
-
Abstract
- The concept of molecular simplification as a drug design strategy to shorten synthetic routes, while keeping or enhancing the biological activity of the lead drug, is applied to (+)-muconin, an acetogenin with remarkable cytotoxicity. A novel method that enables the stereoselective synthesis of such a natural compound or its enantiomer from a common precursor, affording complete stereochemical control and decrease in the number of chemical steps required, is described.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 71
- Issue :
- 6
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.145703384