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Targeted cross-linking of the human beta-globin gene in living cells mediated by a triple helix forming oligonucleotide
- Source :
- Biochemistry. Feb 14, 2006, Vol. 45 Issue 6, 1970-1978
- Publication Year :
- 2006
-
Abstract
- The synthesis of triple helix forming oligonucleotide (TFOs) designed to target a site in the human beta-globin gene, which is the locus for mutations that underlie the beta-globinpathies, including sickle cell anemia is described. The results validate the modification format described and indicate that 2'-O-methylpseudoisocytidine substitutions are an effective solution to problem of targeting genomic sequences containing adjacent cystosines.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 45
- Issue :
- 6
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.146103473