Efficient synthesis of 2'-C-beta-methylguanosine

A systematic variation of reaction conditions that has led to an efficient, straightforward synthesis of 2'-C-beta-methylguanosine with high regio- and stereoselectivity is described. The strategy also improved regioselecitivity in the synthesis of guanosine and might provide a generally useful approach for the synthesis of other guanosine nucleosides by glucosylation.