Homeodomain-mediated [beta]-catenin-dependent switching events dictate cell-lineage determination

Authors :: Olson, Lorin E.; Ohgi, Kenneth A.; Rose, Dave
Tollkuhn, Jessica; Wei Wu; Xue Li
Scafoglio, Claudio; Taketo, Makoto M.; Rosenfeld, Michael G.
Krones, Anna; Kemler, Rolf
Jie Zhang; Grosschedl, Rudolf
Source :: Cell. May 5, 2006, Vol. 125 Issue 3, p593, 13 p.
Publication Year :: 2006
Abstract: An unexpected strategy for [beta]-catenin-dependent regulation of cell-lineage determination based on interactions between [beta]-catenin and a specific homeodomain factor, Prop1, is presented. A novel transcriptional strategy that underlies [beta]-catenin control of cell-lineage determination in organogenesis is discovered during the study.

Subjects :: Catenanes -- Research
Genetic regulation -- Research
Genetic transcription -- Research
Genetic research
Biological sciences

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